How do apigenin, quercetin, and cyanidin-3-O-glucoside affect NAD+ degradation?

By slowing CD38 they may help preserve intracellular NAD levels

Quercetin shows similar effects but with broader antioxidant activity

Cyanidin 3-O glucoside C3G appears to reduce CD38 expression in some models

Less CD38 activity slower NAD breakdown

This can indirectly support sirtuin activity SIRT1/3

Quercetin also influences PARP activity another NAD consumer

These compounds don’t raise NAD they reduce its loss

Quercetin’s bioavailability is lower but still biologically active

The net effect is NAD conservation not production

Think protect the NAD pool rather than constantly refilling it

Diets rich in these flavonoids may support NAD stability

They also support mitochondrial function indirectly

Effects are modest but potentially meaningful over time

This is one reason they’re discussed in longevity circles

Combining them may target CD38 from different angles