How does increased MHC-I expression improve immune surveillance in chronic infections and cancer?

More MHC-I means infected cells present more antigen to CD8 T cells

Tumor cells become easier for cytotoxic T cells to recognize

Viral peptides get displayed more efficiently on the surface

CD8 T cells find targets faster

It strengthens antigen presentation quality

Dormant infections become less invisible.

NK cell balance shifts when MHC-I is restored

It enhances immune discrimination between healthy and abnormal cells

Overall it makes diseased cells more immunologically visible

It helps expose mutated peptides on cancer cells

Cross-presentation benefits from higher baseline expression

Immune scanning becomes more efficient tissue wide

It amplifies immune checkpoint therapy effectiveness